• To our knowledge, this is the first blind and controlled analysis of subcutaneous fat aspiration for the diagnosis of primary systemic amyloidosis. The procedure was performed on 82 patients with biopsy-proved systemic amyloidosis and 72 normal adult volunteers. Slides from 71 of the 72 controls were read as negative. Slides from 59 (72%) of the 82 patients with amyloidosis were read as positive or weakly positive after staining with alkaline Congo red. Subcutaneous fat aspiration was as sensitive as rectal biopsy and substantially more sensitive than bone marrow biopsy in diagnosing amyloidosis. In six instances fat aspiration would have obviated the need for a more invasive diagnostic biopsy. Subcutaneous fat aspiration is sensitive (72%) and specific (99%) for amyloidosis. It is technically simpler and less expensive than rectal biopsy and permits immediate assessment of specimen adequacy. The concordance rate for two independent pathologists was 95%. Equivocally positive stains should be interpreted with caution because weak nonspecific staining may be seen.
(Arch Intern Med 1988;148:929-933)
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 65
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.