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Enalapril, Captopril, and Cough

Michel Andrejak, MD; Marie-Thérèse Andrejak, MD; Gérard Osterman, MD
Arch Intern Med. 1988;148(1):249. doi:10.1001/archinte.1988.00380010251033.
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To the Editor.  —Cough is increasingly reported as a potential side effect of angiotensin-converting enzyme inhibitors.1 Cases of cough have been reported with enalapril as well as with captopril therapy.2-4We report two additional cases of coughing associated with one of these converting-enzyme inhibitors. After introduction of the other inhibitor, the manifestations of coughing promptly recurred following a remission.

Report of Cases. 

—Case 1.  —An 82-year-old woman was given captopril (12.5 mg, three times a day) for the treatment of congestive heart failure since September 1985. During the following winter, an episodic dry cough was noticed. Progressively, the cough became persistent, and was associated with a tickling sensation in her throat. No pulmonary abnormality was found in clinical and radiologic examination, and the congestive heart failure remained controlled. The cough continued and was less and less tolerated, kept the patient awake at night, and persisted throughout the

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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