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Impact of Clonidine on Alcohol Withdrawal States-Reply

Gregory R. Baumgartner, MD; Randall C. Rowen, PharmD
Arch Intern Med. 1988;148(1):245. doi:10.1001/archinte.1988.00380010243031.
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In Reply.  —We would like to thank Dr Stock for his comments on our study. In no way did we wish to imply immediate implementation of clonidine in the management of acute alcohol withdrawal. However, we wish to reiterate our conviction that further research with clonidine for this use is warranted as suggested by our results.We agree that the assessment of specific subjective complaints of alcohol withdrawal has not been standardized. A logistical problem, this is also seen in other detoxifications, as we suggested with our comparisons to opiate withdrawal.1 Standardization of objective clinical assessments for alcohol withdrawal has been suggested by Sellers et al,2 with some agreement. At our institute, we have adopted the Alcohol Withdrawal Scale (AWS) of Cushman et al,3 which we recommend for all controlled trials of this type in an attempt to standardize methodology in this area. The AWS is not


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