• Two patients with severe obstructive sleep apnea syndrome and high-grade proteinuria (>1 g/d [1000 mg/d]) were studied. Three remissions in proteinuria coincided with correction of obstructive sleep apnea syndrome and improvement of blood oxygen levels. These remissions could be dissociated from reductions both in dry body weight and in hematocrit levels. We propose that sleep apnea may cause a functional and reversible type of proteinuria.
(Arch Intern Med 1988;148:87-89)