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Tetracyclines in Therapy of Mycobacterium marinum Infections

Sam T. Donta, MD; Robert E. Levitz, MD; Richard Quintiliani, MD; Philip W. Smith, MD
Arch Intern Med. 1987;147(11):2054. doi:10.1001/archinte.1987.00370110182029.
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To the Editor.  —The editorial "Mycobacterium marinum Infections: A Problem of Recognition, Not Therapy?" by Brown and Sanders1 that appeared in the May 1987 issue of the Archives was in response to our article "Therapy of Mycobacterium marinum Infections: Use of Tetracyclines vs Rifampin" that appeared a year earlier.2 As we feel that the editorial distorts what we said in our article, and as readers unfortunately did not have the opportunity to compare the editorial comments with our article in the same issue, we wished to make the following statements:

  1. Prior to our article, problems with tetracycline therapy had not been emphasized. Two of the four patients described were clearly tetracycline treatment failures, and the other two were unimproved after two weeks of treatment. In the face of other alternatives (eg, rifampin, sulfamethoxazole and trimethoprim), it seemed prudent to offer the suffering patient alternative agents, and we believed

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