We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Enhanced Bleeding With Cefoxitin or Moxalactam: Statistical Analysis Within a Defined Population of 1493 Patients

James A. McGregor, MD, CM
Arch Intern Med. 1987;147(10):1859. doi:10.1001/archinte.1987.00370100173045.
Text Size: A A A
Published online


To the Editor.  —Brown and colleagues1 study of antibiotics and bleeding is astonishing in its methodology and conclusions. The authors make much of the fact that a total of 1493 patients were laboriously followed. Nevertheless, their claims regarding the results of the use of moxalactam are made on the basis of 18 patient histories with a total of two occurrences of decreased hemoglobin concentration and a single patient with increased prothrombin/ partial thromboplastin time. Will readers who get beyond the headlinelike title consider this clinically or statistically relevant?More importantly, Brown and colleagues claim to have controlled for patient "conditions" (nutritional status, etc) and "treatments" (use of anticoagulants, vitamin K) that "could have been associated with bleeding." How can conditions and treatments be meaningfully controlled for without knowledge of why and how patients were treated? Specifically, does not the need for and/or the performance of surgery influence various


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.