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Kinetics of Transdermal Clonidine-Reply

John T. Daugirdas, MD; Subhash Popli, MD; Jessie E. Hano, MD; Todd S. Ing, MD
Arch Intern Med. 1987;147(9):1681-1683. doi:10.1001/archinte.1987.00370090157029.
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—Lin and Ribeiro raise the point that determination of plasma half-life from only a few data points is less than optimal; we agree, but believe that the limited data that we obtained are interpretable and can lead to some useful insights. Using our three data points, we estimated the mean plasma half-lives during days 1 and 2 after the patient had been removed from transdermal therapy to be approximately 34 and 21 hours, respectively. We surmised that the longer plasma half-life during day 1 was due to a skin-depot effect, ie, to continuing absorption of clonidine from the skin at the site of the removed patch.1 Our data are in accord with a study in which a larger number of data points was used to determine plasma half-life after discontinuation of transdermal therapy: MacGregor et al2 found the half-life to average 17 to 20 hours, a value in

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