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ARTICLE |

Reversible Adsorption (Desorption) of Aspirin From Activated Charcoal

Gay A. Filippone, PharmD; Susan S. Fish, PharmD; Peter G. Lacouture, PhD; Joseph M. Scavone, PharmD, MS; Frederick H. Lovejoy Jr, MD
Arch Intern Med. 1987;147(8):1390-1392. doi:10.1001/archinte.1987.00370080026006.
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• The potential desorption of aspirin from activated charcoal was investigated in eight patients in a randomized crossover study. Despite prebinding of aspirin, systemic absorption did occur. Desorption from activated charcoal was characterized by a peak salicylate concentration that was 16% of control and a time to peak salicylate concentration that was delayed in the study group. Bioavailability of aspirin from activated charcoal described by area under the curve was 19% of control. Elimination half-lives were similar in both groups until 12 hours after ingestion, but after 12 hours the half-life of the study group was prolonged while salicylate concentrations were undetectable in the control group. Fifteen percent to 20% of aspirin prebound to charcoal may desorb leading to systemic absorption. Furthermore, release from activated charcoal is initially delayed then sustained through 30 hours.

(Arch Intern Med 1987;147:1390-1392)

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