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Floxacillin-Induced Cholestatic Hepatitis With Evidence of Lymphocyte Sensitization

Rui M. M. Victorino, MD, PhD; Vasco A. Maria, MD; A. Pinto Correia, MD; M. Carneiro de Moura, MD, PhD
Arch Intern Med. 1987;147(5):987-989. doi:10.1001/archinte.1987.00370050179030.
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• A severe and prolonged form of biopsy-proved cholestatic hepatitis occurred in a 45-year-old man who had received floxacillin for two weeks preceding the episode of drug-related cholestatic injury. Immunologic tests revealed evidence of in vitro sensitization to the drug as well as to the serum of a normal subject collected after ingestion of floxacillin. Floxacillin should be added to the list of drugs causing cholestatic hepatitis, most likely by an immunologic mechanism.

(Arch Intern Med 1987;147:987-989)


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