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Article |

Empty Sella in a Case of Werner's Syndrome

Rosa Corcoy, MD; Susan Webb, MD, PhD; Alberto de Leiva, MD, PhD
Arch Intern Med. 1987;147(2):211-212. doi:10.1001/archinte.1987.00370020031022.
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To the Editor.  —Werner's syndrome is a rare, recessively inherited process, characterized by hypogonadism, juvenile cataracts bilaterally, premature aging, graying of the hair, osteoporosis, atrophy of subcutaneous fat and skin of the extremities resembling scleroderma, soft-tissue and vascular calcifications, and nonketotic insulin-resistant diabetes.1-3 We report a case of this syndrome in a 34-year-old man in whom a high resolution computed tomographic (CT) scan of the skull disclosed an empty sella. To our knowledge, this is the first time the association between Werner's syndrome and an empty sella is reported.

Report of a Case.  —The patient's parents were first cousins, and he has a twin sister who is a normal, fertile female. Cataracts that developed during his childhood were operated on during the patient's adolescence and, at age 18 years, his hair was completely gray and sparse. Physical exHigh-resolution computed tomographic scan revealing empty sella with eroded sellar floor.


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