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Pseudoxanthoma Elasticum and Rheumatoid Arthritis

Luisa Praderio, MD; Federjca Marianj, MD; Vittorio Baldini, MD
Arch Intern Med. 1987;147(2):206-207. doi:10.1001/archinte.1987.00370020026017.
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To the Editor.  —Pseudoxanthoma elasticum (PE) is a rare, genetically determined disease with progressive cutaneous, ocular, and arterial lesions.1 Autoimmune thyroiditis but, to our knowledge, no other autoimmune disease, has been sporadically observed in patients with PE.2We report a case of rheumatoid arthritis in a patient who was found to have PE.

Report of a Case.  —A 43-year-old woman whose parents were consanguineous suffered from a symmetrical and deforming polyarthritis, mainly involving her hands and wrists, since she was 21 years of age. In 1983, a diagnosis of seronegative definite rheumatoid arthritis was made, according to the criteria of the American Rheumatism Association. Subsequently, the patient's arthritis worsened, and she was admitted to our clinic in October 1985 because of severe involvement of her left hip.Physical examination revealed typical features of active rheumatoid arthritis. Laboratory studies disclosed the following Top, Prominent juxta-articular osteoporosis and extensive erosive


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