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Diuretics and Blood Pressure

Michael J. Moore, MD
Arch Intern Med. 1987;147(2):202. doi:10.1001/archinte.1987.00370020022011.
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To the Editor.  —The article "Antihypertensive Drug Therapy Withdrawal in a General Population," in the July issue of the Archives, brought to mind several learning experiences of the summertimes of the late 1950s and early 1960s. It had occurred to me that this would be a good time to determine if patients who had reduced their excessive weight and curbed their salt intake might be able to do without their hypertension medications. Diuretics were the principle therapy, and I checked their blood pressure several times weekly. I learned that, whereas it took about two weeks to lower the blood pressure to normal with these agents, it also required about two weeks for the blood pressure to become elevated in those patients whose blood pressure did not remain normal. Thereafter, over a period of six months, most of the patients developed elevated blood pressure again, but a small number of patients


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