0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Comparison of Sublingual Captopril and Nifedipine in Hypertensive Crises

Ramón Pujadas, MD; Javier Jané, MD; Caterina Fornós, MD; Ma Jesús Gago, MD; Nieves de la Concepción, MD
Arch Intern Med. 1987;147(1):175-176. doi:10.1001/archinte.1987.00370010173038.
Text Size: A A A
Published online

To the Editor.  —The recent demonstration by Tschollar and Belz1 that treatment of hypertensive crises with sublingual captopril induces a safe and rapid lowering of blood pressure (BP) suggests the need for prospective studies clinically comparing sublingual captopril with nifedipine. In the first comparative study, Hauger-Klevene2 concluded that the hypotensive effect of sublingual nifedipine therapy occurs earlier but has a shorter duration than that of sublingual captopril.In a randomly conducted, doubleblind study, we compared the hypotensive effect of sublingual captopril and nifedipine in 50 consecutive patients with acute hypertensive crises treated in a hospital emergency room. All patients had essential hypertension and a mean BP higher than 130 mm Hg in two different measurements five minutes apart. Equiparable captopril or nifedipine powder capsules for clinical investigation were prepared in the pharmacy department. We administered to each patient an initial capsule, containing either 25 mg of captopril or

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();