We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Effects of Sickle Cell Anemia on Conjunctival Oxygen Tension and Temperature

Sherwin J. Isenberg, MD; William E. McRee, MD; Michael S. Jedrzynski, MD; Steven N. Gange, MD; Sherri L. Gange, MD
Arch Intern Med. 1987;147(1):67-69. doi:10.1001/archinte.1987.00370010071018.
Text Size: A A A
Published online


• Because conjunctival vessels are affected by sickle cell disease, we wanted to see if conjunctival Po2 (partial oxygen tension) and temperature were also affected and if these measurements could aid in managing these patients. Conjunctival Po2 and temperature in 23 asmptomatic homozygous patients with sickle cell anemia did not differ significantly from those in age-matched controls. However, 12 subjects in painful sickle cell crisis had a significantly lower conjunctival Po2 than before crisis despite no significant change in hematocrit and conjunctival temperature. Supplemental oxygen therapy significantly increased conjunctival Po2. When supplemental oxygen was removed, conjunctival Po2 decreased to the admission level despite clinical improvement. This finding supports the use of supplemental oxygen in treating crisis. Measuring conjunctival Po2 can give clinicians an assessment of the effect of sickle cell disease on a peripheral capillary bed and may provide the first objective method to reliably diagnose acute painful sickle cell crisis.

(Arch Intern Med 1987;147:67-69)


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

4 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.