Pure Red Blood Cell Aplasia: Response to Intravenous Immunoglobulins, a Blocking Antibody

Suresh B. Katakkar, MD
Arch Intern Med. 1986;146(11):2288. doi:10.1001/archinte.1986.00360230234038.
Text Size: A A A
Published online

To the Editor.  —A young man, 21 years of age, was diagnosed as having pure red blood cell aplasia at the University of New Mexico, Albuquerque, and at the University of Arizona, Tucson, in 1974 and 1983, respectively.The patient had been treated with prednisone therapy (80 mg/d) with intermittent blood transfusions. From September 1983 to January 1984, it was noted that despite prednisone therapy he required blood transfusions every ten to 15 days to maintain a hematocrit value of 25% (0.25).Over the years, he has developed multiple antibodies due to multiple blood transfusions. As a result of longterm therapy with corticosteroids, the patient has bilateral avascular necrosis of the femoral heads; hence, increasing the corticosteroid dose was not appropriate. A splenectomy was performed to increase the useful life of transfused red blood cells, even though the patient's spleen was not enlarged. As an incidental finding, it was noted


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.