We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Limitations of Hemofiltration in Digoxin Overdose-Reply

Kar N. Lai, MD; Ramasamyiyer Swaminathan, MBBS; Chiu O. Pun, MBBS; John Vallance-Owen, MD
Arch Intern Med. 1986;146(11):2287-2288. doi:10.1001/archinte.1986.00360230233037.
Text Size: A A A
Published online


—We agree with the comment of Doherty and Conrad that the amount of digoxin removed by hemofiltration for 21 hours was minute despite the modest fall in the serum digoxin level. The digoxin concentration during maintenance therapy is much lower in skeletal muscle than in the myocardium despite the fact that skeletal muscle forms the largest storage depot of digoxin. The ratio between the concentrations in the plasma and the heart is reportedly between 1:30 and 1:200.1 As the cardiotoxicity is due to interaction of cardiac glycoside with the cellular receptor, the effective and progressive removal of drug from receptor sites as the drug-receptor equilibrium is displaced in the direction of dissociation is essential in reversing digoxin cardiotoxicity.2 Immediate removal of digoxin from other body depots such as skeletal muscle is therefore of lesser importance in the acute management of these critically ill patients. The exact quantitative


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.