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Intensive Hospital Monitoring Study of Intravenous Cimetidine

Jane B. Porter, MS; Keith Beard, MB, ChB, MRCP; Alexander M. Walker, MD, DrPH; David H. Lawson, MD, FRCP; Hershel Jick, MD; Gavin S. M. Kellaway, MD
Arch Intern Med. 1986;146(11):2237-2239. doi:10.1001/archinte.1986.00360230177025.
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• We studied the frequency of adverse reactions occurring in 1189 patients who received cimetidine intravenously, based on data collected as part of a hospital-based monitoring study of recently marketed drugs. There were 40 patients (3.4%) with adverse reactions, 23 of whom were considered to be "definitely" or "probably" related to cimetidine use and 17 patients in whom a causal association was possible. The most frequently reported reactions were neuropsychiatric disorders in 19 patients (1.6%) and leukopenia in eight patients (0.7%).

(Arch Intern Med 1986;146:2237-2239)


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