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Long-term Survival in Multiple Myeloma

Joan Bladé, MD; Ciril Rozman, MD; Emili Montserrat, MD
Arch Intern Med. 1986;146(8):1637-1638. doi:10.1001/archinte.1986.00360200217047.
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To the Editor.  —Although about 15% to 20% of patients with multiple myeloma (MM) survive for five or more years, there are few reports of patients with this disease surviving for more than ten years.1,2 The recent article published in the November 1985 Archives by Alexanian3 describing a series of 13 patients with MM surviving at ten years of diagnosis prompted us to report three such patients from our own series of 95 cases of symptomatic MM, diagnosed from January 1960 to December 1975.The patients' initial characteristics are shown in the Table. Patient 1 died 11.5 years after diagnosis with progressive disease, and patients 2 and 3 are still alive. Patients 1 and 2 were treated with melphalan, and patient 3 received cyclophosphamide. In addition, radiation therapy for local lesions was given to patients 1 and 2. All three patients had an objective response to therapy, and patient


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