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Carbimazole-Induced Cholestatic Hepatitis

C. Aynsa, MD; R. Diaz de Otazu, MD; J. M. Cia, MD
Arch Intern Med. 1986;146(7):1455. doi:10.1001/archinte.1986.00360190247047.
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To the Editor.  —In the August 1985 issue of the Archives, Blom et al1 reported a case of carbimazole-induced intrahepatic cholestasis and stated that this condition has been reported on only three previous occasions.2-4 We have found two additional reports5,6 on cholestatic effects of carbimazole, probably because carbimazole is mainly used in Europe, as is methimazole in the United States. In this report, we describe a case of cholestatic hepatitis induced by carbimazole.

Report of a Case.  —Our patient was a 45-year-old woman with a toxic thyroid nodule. Carbimazole therapy, 20 mg/d, was started before thyroidectomy. Ten days later, jaundice developed. Physical examination revealed hepatomegaly (2 cm below the costal margin) and laboratory evaluation disclosed the following values: total bilirubin, 1.8 mg/dL (30.78 μmol/L (conjugated, 0.8 mg/dL [13.68 μmol/L]); alkaline phosphatase, 241 IU/L (normal, 30 to 140 IU/L; γ-glutamyltransferase, 157 IU/L (normal, 12 to 25 IU/L); aspartate

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