Magnesium Depletion and Thiazide Hypokalemia

Bruce R. Leslie, MD
Arch Intern Med. 1986;146(5):1025-1026. doi:10.1001/archinte.1986.00360170283043.
Text Size: A A A
Published online

To the Editor.  —In their article in the November 1985 issue of the Archives, Papademetriou et al1 consider several possible explanations for the failure of oral potassium chloride to correct diuretic-induced hypokalemia. An explanation not mentioned was the possibility of coexistent diuretic-induced magnesium depletion.Thiazide diuretics are magnesuric,2 and, when accompanied by insufficient dietary intake, may create a negative magnesium balance. Magnesium is largely an intracellular cation, and serum magnesium concentrations correlate poorly with intracellular stores. Experimental magnesium deficiency in man has been associated with hypokalemia and negative total body potassium balance.3 Enhanced urinary potassium excretion has been reported in experimental magnesium depletion.4Hypokalemia refractory to oral potassium chloride supplements may have been due to coexistent diureticinduced magnesium depletion. Magnesium depletion may be of additional importance in the pathogenesis of diuretic-induced ventricular arrhythmias that may also be refractory to potassium supplementation.5


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.