0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Single-Dose Antibiotic Therapy for Urinary Tract Infections and Type II Error-Reply

John T. Philbrick, MD; James P. Bracikowski, MD
Arch Intern Med. 1986;146(2):413-414. doi:10.1001/archinte.1986.00360140269044.
Text Size: A A A
Published online

—Ms Jordan seems to take issue with our conclusion that single-dose trimethoprim-sulfamethoxazole treatment of uncomplicated urinary tract infections in women is less effective than the conventional multiple-dose therapy. We agree that, from the results of our analysis, the cure rate for single-dose therapy at 87% appears to be quite similar to the cure rate of 90% for multiple-dose therapy. We agree that even if the difference in these two rates were statistically significant, the clinician would probably perceive it to be clinically insignificant. However, our conclusion that single-dose therapy with trimethoprim-sulfamethoxazole is likely to be less effective than multiple-dose therapy is based on the real possibility of a type II error from our analysis (95% confidence interval, with single-dose therapy of 78% to 92% and with multiple-dose therapy of 81% to 95%). We also based this conclusion on the report of the well-done randomized trial by Schultz et al1

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();