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Histomorphometric Evaluation of Reversible Heparin-Induced Osteoporosis in Pregnancy

Ari Zimran, MD; Shmuel Shilo, MD; Drora Fisher, MD; Itai Bab, DMD
Arch Intern Med. 1986;146(2):386-388. doi:10.1001/archinte.1986.00360140226033.
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• Transilial bone biopsy confirmed heparin-induced osteopenia in a 23-year-old postpartum patient. Histomorphometric measurements during the reversible stage of bone disease that followed discontinuation of the heparin sodium therapy revealed signs of recovery; these were superimposed on a loose trabecular structure typical of osteoporosis. The histomorphometric evidence of recovery correlated well with signs of clinical improvement. In the majority of patients, heparin therapy during pregnancy is innocuous; however, discontinuation of treatment is recommended at the earliest signs of osteoporosis.

(Arch Intern Med 1986;146:386-388)


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