Meningeal involvement is a rare complication of multiple myeloma. None of the previously described patients presenting this syndrome had responded to treatment. We describe a 64-year-old man with meningeal myelomatosis. A favorable response to treatment was produced by radiation therapy administered to the head and by intrathecal and systemic chemotherapy including high-dose corticosteroids.
(Arch Intern Med 1986;146:194-196)