Amyloid Deposition in Serosal Membranes

Hubert Mallet, MD; Philippe Humbert, MD; Jean-Louis Dupond, MD; Robert Leconte Des Floris, MD
Arch Intern Med. 1985;145(12):2264. doi:10.1001/archinte.1985.00360120136031.
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To the Editor.  —We read with interest the case reported by Weinrauch et al,1 and would like to share in the clinical description of serosal amyloid locations.We recently reported a case of serosal amyloidosis in a 56-year-old woman with an M component.2 The patient had been hospitalized in 1981 because of monoclonal IgA λ-peak (2.4 g/dL) without criteria of multiple myeloma or lymphoma. Bone marrow aspiration revealed 7% dysmorphic plasma cells. Amyloid deposition was present in the kidney and in hepatic parenchyma. The rectal biopsy specimen was also positive.Ten months later, the patient was admitted to the hospital for ascites and a right pleural effusion. The drainage of both effusions showed a sterile fluid with characteristics of an exudate (3.2 dL of protides; white blood cell count, 50/cu mm with 92% lymphocytes). The fluid's electrophoresis revealed the same typical peak. Histopathologic results included peritoneal amyloid. Pleural


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