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Propylthiouracil-Associated Hepatitis

Clifford A. Bloch, FCP(SA); Laura J. Jenski, PhD; William F. Balistreri, MD; Lawrence M. Dolan, MD
Arch Intern Med. 1985;145(11):2129-2130. doi:10.1001/archinte.1985.00360110205048.
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To the Editor.  —We read with interest the article by Hanson1 in the May 1984 Archives wherein he reviewed the literature on hepatitis associated with propylthiouracil. We concur that propylthiouracil-induced hepatitis is a difficult diagnosis to establish and agree with the practical diagnostic criteria that he proposed. We believe we recently encountered the first male child with propylthiouracil-associated hepatitis. This would tend to suggest that the higher incidence of propylthiouracil-induced reactions among female patients merely reflects the predominance of female patients being treated medically for hyperthyroidism.

Report of a Case.  —Our patient was a 12-year-old boy who presented with a three- to four-week history of symptoms of hyperthyroidism and unilateral mild exophthalmos. Physical examination confirmed the presence of moderate toxicity. His thyroid gland felt smooth and was diffusely enlarged, measuring 3 × 2 cm in each lobe. A bruit was audible over the gland. Laboratory data revealed a serum


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