0
ARTICLE |

The Optimal Antithrombotic Dose of Aspirin

Jack Hirsh, MD
Arch Intern Med. 1985;145(9):1582-1583. doi:10.1001/archinte.1985.00360090046005.
Text Size: A A A
Published online

Clinical trials over the last decade have demonstrated that aspirin is an effective antithrombotic agent. Aspirin irreversibly inhibits the enzyme cyclo-oxygenase, which in the platelet is responsible for the production of thromboxane A2, a platelet-aggregating agent; and, in vascular wall cells, cyclooxygenase is responsible for the production of prostacyclin (PGI2), an inhibitor of platelet aggregation. Thus, aspirin has the potential to be both antithrombotic and thrombogenic. Low doses of aspirin (325 mg or less) inhibit cyclo-oxygenase in platelets and vascular wall cells, but the inhibitory effect on platelet thromboxane A2 synthesis is greater and lasts longer than its effect on vascular wall PGI2 synthesis.1

The therapeutic importance of inhibiting PGI2 may have been overestimated in the past. Experimentally, aspirin is only thrombogenic at very high doses2 (200 mg/kg), which far exceed the minimum dose required to inhibit PGI2 production. This suggests that inhibition of PGI2 production may not be the

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();