Behçet's Disease Preceded by Fever of Unknown Origin

Maya Gotfried, MD; HZHAK Jutrin, MD; Mordchai Ravid, MD
Arch Intern Med. 1985;145(7):1329. doi:10.1001/archinte.1985.00360070211038.
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To the Editor.  — Behçet's disease, first described in 1937, is best defined as a clinical triad of recurrent ocular inflammation, oral and vaginal ulcers, and a cutaneous hyperreactivity to minor trauma.1 A myriad of additional features was described in individual patients, including arthritis, colitis, various forms of vasculitis, venous thrombosis, and amyloidosis. Fever may accompany other acute manifestations during the course of the disease2,3; however, to the best of our knowledge, it has never been described as a sole manifestation preceding the other phenomena.

Report of a Case.  —A 27-year-old woman was admitted for investigation of fever of eight weeks' duration. Physical examination was notable only for a palpable spleen, 5 cm below the costal margin. Blood pressure was 120/80 mm Hg; pulse, 95 beats per minute and regular; and temperature, 38.5 °C. The erythrocyte sedimentation rate was 30 mm/hr (Westergren). The hemoglobin level was 12.6 mg/dL


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