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Captopril vs Mild to Moderate Hypertension

Amber Arlington, MPH, MD
Arch Intern Med. 1985;145(6):1141-1142. doi:10.1001/archinte.1985.00360060209042.
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To the Editor.  In the October 1984 Archives, a Veterans Administration Cooperative Study Group on Antihypertensive Agents1 published an article on the treatment of mild to moderate hypertension with low-dose cap- topril. The study only included patients with pretreatment diastolic blood pressures between 92 and 109 mm Hg and concluded that such patients with mild to moderate hypertension can be treated adequately with half of the currently recommended dosage of captopril.I question the validity of their study, as I question whether the patients identified should have been treated at all. An earlier Veterans Administrative Cooperative Study2 demonstrated no significant benefit in treating patients with pretreatment diastolic blood pressures between 90 and 104 mm Hg, with respect to the prevention of complications of hypertension and the reversal of pretreatment secondary changes. These findings were again supported by a US Public Health Service Hospitals Cooperative Study Group, as cited by Smith.3

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