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Hepatic Vein Obstruction in Idiopathic Hypereosinophilic Syndrome

Lisa Elouaer-Blanc, MD; Elie-Serge Zafrani, MD; Jean-Pierre Farcet, MD; Marie-France Saint-Marc Girardin, MD; Didier Mathieu, MD; Daniel Dhumeaux, MD
Arch Intern Med. 1985;145(4):751-753. doi:10.1001/archinte.1985.00360040189042.
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• We report an association between idiopathic hypereosinophilic syndrome and obstruction of the hepatic veins (Budd-Chiari syndrome). Budd-Chiari syndrome was assessed by liver biopsy and hepatic phlebography and documented by computed tomography. Postmortem examination revealed fibrous occlusion of the hepatic venous tree, as well as fibrosis of the endocardium and of myocardial and pulmonary vessels. To our knowledge, the association between idiopathic hypereosinophilic syndrome and Budd-Chiari syndrome has never previously been reported. Since it has been suggested that hypereosinophilia might cause endothelium damage, a link between these two entities is postulated.

(Arch Intern Med 1985;145:751-753)

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