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B-Cell Lymphoma in Two Monogamous Homosexual Men

Alexandra M. Levine, MD; Ronald L. Burkes, MD; Martin Walker, MD; Paul R. Meyer, MD; Parkash S. Gill, MD; Peter W. Nichols, MD; Ruth Dworsky, RN; John W. Parker, MD; Robert J. Lukes, MD
Arch Intern Med. 1985;145(3):479-481. doi:10.1001/archinte.1985.00360030123022.
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• Opportunistic infections and malignant neoplasms have been described in homosexual men in association with immunologic abnormalities. We observed the development of malignant B-cell lymphomas in two homosexual men who had had a monogamous relationship for two years. Patient 1 had an aggressive, monoclonal, small, noncleaved, non-Burkitt's lymphoma ("undifferentiated lymphoma"), associated with severe immunocompromise. Patient 2 manifested a monoclonal, small, cleaved, follicular center cell lymphoma, with a follicular pattern, two months later. No common acute infection was detected. Staining for Epstein-Barr nuclear antigen in malignant tissue was negative in the second patient. However, the possibility of a transmissible agent as a causative factor cannot be excluded, and further study of similar patients is warranted.

(Arch Intern Med 1985;145:479-481)


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