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Colchicine Therapy for Refractory Idiopathic Thrombocytopenic Purpura

S. Vance Strother, MD; Kenneth S. Zuckerman, MD; Albert F. LoBuglio, MD
Arch Intern Med. 1984;144(11):2198-2200. doi:10.1001/archinte.1984.04400020110017.
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• Fourteen patients with Idiopathic thrombocytopenic purpura (ITP) refractory to splenectomy and corticosteroids (prednisone, 1 to 2 mg/kg of body weight per day) received at least 1.2 mg of oral colchicine daily for a minimum of two weeks. Three patients had complete responses and one had a partial response (response rate, 29%). Responses were evident within two weeks of commencing therapy. Only the patient with a partial response was receiving concomitant therapy, a stable dose of prednisone. Responsiveness to colchicine did not seem to correlate with responsiveness to vincristine sulfate. Side effects of colchicine therapy were mild and complications did not occur. A possible mechanism of action for colchicine in ITP is decreased clearance of opsonized platelets secondary to inhibition of microtubule-dependent events In macrophages. Colchicine Is useful in the treatment of ITP resistant to standard treatment.

(Arch Intern Med 1984;144:2198-2200)


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