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Theophylline Interaction With H2 Receptor Antagonists

Ralph M. Myerson, MD; John J. Seaman, PharmD; William O. Frank, MD
Arch Intern Med. 1984;144(10):2094-2095. doi:10.1001/archinte.1984.04400010221043.
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To the Editor.—We read with inter[ill] the recent article by Powell et al1 garding the effects of ranitidine [ill] cimetidine on theophylline meta[ill] lism. A number of reports have b[ill] published regarding cimetidine's teraction with theophylline,2,3 ranitidine has yet to undergo as ext[ill] sive an investigation of this poten[ill] problem.

Breen and colleagues,4 using me[ill] odologies similar to those employed Powell et al,1 demonstrated a 9% crease in the systemic clearance theophylline and a slightly long mean elimination half life in subje[ill] pretreated with ranitidine compa[ill] with a control period. They, howe[ill] employed only a single dose of ophylline and therefore were unable report on a steady-state regimen of [ill]o drugs. One might expect to see an centuation of any effects in the [ill]eady-state condition. Breen et al also [ill]int out that the molar ratio of [ill]netidine and ranitidine was 4.2:1 and [ill]ggest that it


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