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Antituberculosis Drugs and Breast-feeding

Mack R. Holdiness, PhD
Arch Intern Med. 1984;144(9):1888. doi:10.1001/archinte.1984.00350210218046.
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To the Editor.  —In the March Archives, Snider and Powell1 presented a well-organized review of the sparse and scattered data available in the literature concerning the appearance of antituberculosis drugs in human breast milk. The information available to these authors indicated that p-aminosalicylic acid and pyrazinamide were either not detectable or unknown at the time of publication; however, my laboratory has recently analyzed both of these components in human breast milk.A 27-year-old woman (non-breast-feeding) was given 4 g of p-aminosalicylic acid and breast milk collected at 0, 1, 2, 3, 4, 9, and 12 hours following oral administration. A maximum concentration of 1.1 mg/L was obtained at three hours with an elimination halflife of 2.5 hours. The maximum plasma concentration of the mother at two hours was determined to be 70.1 mg/L. Gastrointestinal tract irritation later developed and the p-aminosalicylic acid was withdrawn from the


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