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Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia

Burke J. Brooks Jr, MD; Hal E. Broxmeyer, PhD; Christopher F. Bryan, PhD; Stephen H. Leech, MD, PhD
Arch Intern Med. 1984;144(7):1474-1477. doi:10.1001/archinte.1984.00350190172030.
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• Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient's disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

(Arch Intern Med 1984;144:1474-1477)


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