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Value of Positive Serologic Findings for Toxoplasmosis in the Immunocompromised Host

Ramon Estruch, MD; Jordi Casademont, MD; Alvaro Urbano-Marquez, MD; Ciril Rozman, MD
Arch Intern Med. 1984;144(3):660. doi:10.1001/archinte.1984.00350150273064.
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To the Editor.  —In the June 1983 Archives, Peacock et al1 described a 72-year-old man who had chronic granulocytic leukemia with IgG indirect fluorescent antibody (IFA) titers against Toxoplasma gondii greater than 1:100,000. This patient did not manifest any clinical toxoplasmosis, and his postmortem histopathologic studies failed to demonstrate any tissue T gondii trophozoites.1 We describe a patient who had immunoblastic sarcoma with IgG and IgM IFA titers against T gondii and who did not manifest any pathologic evidence of T gondii infection.

Report of a Case.  —A 76-year-old woman was admitted to the hospital with a four-week history of progressive confusion and headaches. She had had a five-year previous diagnosis of Sjögren's syndrome that evolved to immunoblastic sarcoma two years later. Six cycles of combined therapy with cyclophosphamide, vincristine sulfate, and prednisone were administered. The patient showed complete response and remained asymptomatic during the last six months


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