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Anesthetic and Surgical Risk in Hypothyroidism-Reply

Andrew D. Weinberg, MD
Arch Intern Med. 1984;144(3):660. doi:10.1001/archinte.1984.00350150271063.
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In Reply.  —We appreciated reading Dr Litt and Dr Roizen's comments on our study. Obviously, a larger number of patients in any retrospective study would be desirable. However, we proceeded with a retrospective design precisely because research was lacking in the field. The careful selection of controls for this study, matched for age, sex, and type of surgery and surgeon or surgical team, was done to help isolate the risk encountered by patients with untreated hypothyroidism who were undergoing surgery.We stand by the validity of both McNemar's test (matched-pair analysis) and the signed-rank test in reference to our results. These tests take into account population size and were used to test for significance each of ten preoperative, perioperative, and postoperative variables.1We agree with Drs Litt and Roizen's comment that, as with most studies, the more subjects involved, the greater the chances of making accurate, significant, and meaningful


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