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Article |

Successful Combination Chemotherapy for Metastatic Parathyroid Carcinoma

Ronald M. Bukowski, MD; Leslie Sheeler, MD; James Cunningham, MD; Caldwell Esselstyn, MD
Arch Intern Med. 1984;144(2):399-400. doi:10.1001/archinte.1984.00350140229032.
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• A 54-year-old patient with metastatic parathyroid carcinoma and severe hypercalcemia refractory to conventional treatment was treated with chemotherapy consisting of fluorouracil, 500 mg/sq m intravenously (IV) daily for four days (24-hour infusion), cyclophosphamide, 500 mg/sq m IV daily for four days, and dacarbazine (imidazole carboxamide), 200 mg/sq m IV daily for four days. Complete objective and partial biochemical responses were noted, with the response duration being 5.0+ months. The toxic reaction was moderate and predominantly gastrointestinal.

(Arch Intern Med 1984;144:399-400)


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