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Pheochromocytoma Resistant to a-Adrenergic Blockade

Jonathan B. Hauptman, MD; Robert S. Modlinger, MD; Norman H. Ertel, MD
Arch Intern Med. 1983;143(12):2321-2323. doi:10.1001/archinte.1983.00350120115025.
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• In a 54-year-old man with a norepinephrine-secreting pheochromocytoma, resistance developed to the α-adrenergic blocking agent, phenoxybenzamine hydrochloride. Dosages of 240 mg/day were ineffective. Intravenous phentolamine mesylate reduced his BP at first, but resistance developed to this also. Therapy with α-methylparatyrosine, an inhibitor of catecholamine biosynthesis, finally controlled his BP, and the tumor was removed.

(Arch Intern Med 1983;143:2321-2323)


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