December 1983, Vol 143, No. 12 >

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ARTICLE | December 1983

Can the Pituitary Release Adrenocorticotropic Hormone During Stress?

Stephen R. Newmark, MD

Arch Intern Med. 1983;143(12):2248-2249. doi:10.1001/archinte.1983.00350120038009.

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The hypothalamic-pituitary-adrenal axis is frequently used as an example of a model system involving a negative-feedback control loop. In this model, a perceived decreased circulating or cellular concentration of glucocorticoids at the level of the hypothalamus or pituitary is followed by a release of corticotropin-releasing factor (CRF) and/or adrenocorticotropic hormone (ACTH) with subsequent stimulation of adrenal cortisol secretion. Conversely, elevated adrenal glucocorticoid secretion or exogenous glucocorticoid administration will decrease and subsequently suppress CRF and ACTH release. The site of glucocorticoid-induced CRF-ACTH suppression has not been definitively identified but is believed to involve loci in the cerebral cortex, hippocampus, amygdala, and other sites in the limbic system, as well as the hypothalamus and pituitary.¹

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Newmark SR. Can the Pituitary Release Adrenocorticotropic Hormone During Stress?. Arch Intern Med. 1983;143(12):2248-2249. doi:10.1001/archinte.1983.00350120038009.

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