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ARTICLE |

Antibodies to Herpes Simplex Type 1 in Patients With Active Duodenal Ulcer

Kenneth H. Rand, MD; Dan G. Jacobson, MD; C. Raymond Cottrell, MD; Kenneth L. Koch, MD; Ralph T. Guild, MD; James E. McGuigan, MD
Arch Intern Med. 1983;143(10):1917-1920. doi:10.1001/archinte.1983.00350100085019.
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• One hundred seventy-two patients requiring upper gastrointestinal tract endoscopy were examined prospectively for evidence of herpes simplex virus type 1 (HSV-1) infection. No viruses were recovered from active ulcers (11 with duodenal and eight with gastric ulcers). Using both enzyme-linked immunosorbent assay (ELISA) and standard complement fixation methods, patients with endoscopically proved active duodenal ulcer had significantly higher mean serum antibody levels to HSV-1 (but not to cytomegalovirus) than those without evidence of peptic ulcer. Neither patients with a history of or evidence of past peptic ulcer nor those with active gastric ulcer had higher serum antibody levels to HSV-1 compared with subjects without ulcers. These data provide support for an association between active duodenal ulcer and HSV-1 infection, the nature of which is not defined by these studies.

(Arch Intern Med 1983;143:1917-1920)

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