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Clinical Implications of Large Vegetations in Infectious Endocarditis

David Wong, PharmD, MD; P. Anthony; N. Chandraratna, MD; Rodney M. Wishnow, MD; Visith Dusitnanond, MD; Ananda Nimalasuriya, MD
Arch Intern Med. 1983;143(10):1874-1877. doi:10.1001/archinte.1983.00350100036011.
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• Thirty-four patients with clinical infectious endocarditis were examined by M-mode and two-dimensional (2D) echocardiography. Vegetations were identified in 16 patients (47%) by M-mode and in 27 patients (87%) by 2D echocardiography. Vegetations identified by 2D echocardiography were categorized as small (<5 mm), medium (5 to 9 mm), or large (≥10 mm). Large vegetations were caused by a variety of organisms, had a higher incidence of surgery (44% v 0%), and had no increased incidence of stroke or death. The larger the vegetation, the more detectable it was by M-mode. Aortic valve vegetations were associated with a higher incidence of congestive heart failure (CHF) (67% v 14%) and stroke (44% v 9%). Four patients with large aortic valve vegetations had the highest complication rate; CHF developed in all four, two had valve replacement, one had a stroke, and two died.

(Arch Intern Med 1983;143:1874-1877)


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