Skin Reactions to Phytohemagglutinin in the Healthy Elderly Subject and in the Immunodeficient Subject

Ivo Krč, MD; Iva Matoušková, ScD; Dagmar Pa[unk]chová
Arch Intern Med. 1983;143(5):1074. doi:10.1001/archinte.1983.00350050244054.
Text Size: A A A
Published online

To the Editor.  —Phytohemagglutinin (PHA) is an agent mostly used for in vitro testing of lymphocyte transformation. Less attention has been paid to its possible use as a nonspecific skin antigen for the in vivo assessment of delayed-type hypersensitivity.1,2 Similarly to the common recall antigens, ie, PPD, streptokinase-streptodornase, candidin, and others, the intradermal inoculation of PHA causes perivascular cell infiltration consisting of both polynuclear and mononuclear cells, with some lymphocytes developing to blastlike cells.1In the February Archives (1982; 142:291-293), Burke et al, in an article entitled "Immune Responses to Varicella-Zoster in the Aged," comment on the skin reactions to intradermal injections of PHA in healthy volunteers and in immunologically compromised patients. As far as the healthy aged subjects are concerned, their results are fully in agreement with our investigation,3 carried out in a nursing home for the elderly. We have observed normal PHA skin responses even


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.