March Myoglobinemia-Reply

I. Melamed, MD
Arch Intern Med. 1983;143(2):390. doi:10.1001/archinte.1983.00350020220051.
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In Reply.  —We did not conclude that intensive physical conditioning programs cause chronic renal function deterioration. According to our results, persistent myoglobinemia may lead to a deterioration in renal function, but not to chronic renal failure. Our recruits were followed up for a long period and we have noticed a gradual improvement in their renal function.It is true that millions of people undergo physical training, but the severity of the conditions vary greatly from one region to another.Dr Knochel is right in saying that acute renal failure caused by exertional rhabdomyolysis is rare, but it has led other investigators to look for the change following regular exercise and, to our knowledge, there are few works in which such a population have been followed for any prolonged period.Our conclusion is that prolonged, repetitive exertion is followed by a decrease in renal function, and we can compare that with


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