To the Editor.
—Your timely and interesting editorial entitled "Case Reports of Untoward Drug Reactions, Adverse Events, and Rare Diseases," which was published in the July Archives (1982;142:1271-1272), stressed the difficulties in selecting manuscripts for publication (eg, not the "sixth case"). You also acknowledge the problem of the quality of articles and the importance of peer review.This problem of informative value is by no means limited to single-case studies. As shown by Venulet et al,1 only 61% of 5,737 articles (from 80 countries) on larger series of patients included information on the number of patients treated and the number of patients with adverse reactions and in only 55% was the incidence of each adverse reaction given. Inclusion of such basic, but relevant, items, eg, age and doses, duration of treatment, and galenic form, cut the proportion of articles providing all these data to 19%. Differences in completeness of