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Article |

Classic Gout in Hageman Factor (Factor XII) Deficiency

David Green, MD, PhD; Christiane L. Arsever, MD; Kenneth A. Grumet, MD; Oscar D. Ratnoff, MD
Arch Intern Med. 1982;142(8):1556-1557. doi:10.1001/archinte.1982.00340210154028.
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A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.

(Arch Intern Med 1982;142:1556-1557)


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