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Gallium Scan v Indium 111-Labeled Oxyquinoline WBC Scan

I. Ross McDougall, MB, ChB, PhD; David A. Goodwin, MD
Arch Intern Med. 1982;142(7):1407-1408. doi:10.1001/archinte.1982.00340200177039.
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To the Editor.  —We would like to comment on the article entitled "The Gallium Scan: Problems and Misuse in Examination of Patients With Suspected Infection" by Ebright et al published in the February Archives (1982;142:246-254). About the time they began their study, we stopped doing gallium citrate Ga 67 scans for precisely the reasons outlined in their article, namely, difficulty in interpretation and low specificity. Factors that contribute to the problem of specificity of 67Ga include excretion of a substantial proportion of radioactivity through the colon and uptake in neoplasms and in healing wounds. Because of these problems, we have relied almost entirely on 111In—labeled oxyquinoline WBC scans for detection of occult abscesses.This technique is not as simple to use as 67Ga, since it requires separation of a polymorphonuclear-enriched fraction of the patient's blood (40 mL of venous blood is sufficient), labeling the cells with 111


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