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Typhoid Hepatitis With Immunoglobulins and Complement Deposits in Bile Canaliculi

Michael Dan, MD; Simon Bar-Meir; Medina Jedwab, MD; Shlomo Shibolet, MD
Arch Intern Med. 1982;142(1):148-149. doi:10.1001/archinte.1982.00340140150027.
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• Documented typhoid fever in a 26-year-old patient was complicated by acute hepatitis with unusually profound jaundice. Liver biopsy revealed focal cell necrosis, mononuclear cell infiltration, Kupffer cell proliferation, and mild cholestasis. Immunofluorescent studies of the liver biopsy revealed deposits of IgG, IgA, IgM, and C3 in the bile canaliculi, suggesting a role for damage by immune complexes in typhoid hepatitis.

(Arch Intern Med 1982;142:148-149)


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