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Permanent Remission of Ketotic Diabetes With Subsequent Normal C-Peptide Secretion

Lillian Harstine, MD; John A. D'Elia, MD; Thomas Aoki, MD
Arch Intern Med. 1981;141(7):960-961. doi:10.1001/archinte.1981.00340070140036.
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To the Editor.  —Juvenile diabetics is initially seen with fatigue, weight loss, increased thirst, frequent urination, and glycosuria-ketonuria with or without ketoacidosis. Initially, the insulin secretory function is minimal despite hyperglycemia. Many diabetics enter a transient period of remission (the honeymoon period) within several months, but their conditions eventually deteriorate to a state of total insulin deficiency. A young man examined for remission showed evidence of a diabetes cure.

Report of a Case.  —An 18-year-old man was seen initially at the Joslin Clinic on June 29, 1973, for evaluation of diabetes mellitus. He had polyuria, polydipsia, fatigue, leg cramps, and had had a 23-kg weight loss from 108 kg. He had been hospitalized at another hospital for three weeks, with an admission blood glucose level of 441 mg/dL associated with glycosuria (4 + ) and ketonuria. Serum electrolyte levels were normal. He received a 2,400-calorie/day diet, and his condition was regulated with


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