Combination Therapy With Ticarcillin and Sulfamethoxazole-Trimethoprim for Infections in Patients With Cancer

Michael J. Keating, MD; Ronald Lawson, MD; William Grose, MD; Gerald P. Bodey, MD
Arch Intern Med. 1981;141(7):926-930. doi:10.1001/archinte.1981.00340070106021.
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• Intravenous (IV) antibiotic therapy with a combination of ticarcillin disodium and sulfamethoxazole-trimethoprim was administered as initial empiric treatment of 218 febrile episodes in patients with cancer. Seventy-nine (77%) of 102 episodes of infection were cured, and the temperature returned to normal in 88 (74%) of 199 febrile episodes without proved infection. The response rates for the major sites of infection were as follows: septicemia, 89%; pneumonia, 52%; soft-tissue infections, 85%; and urinary tract infections, 100%. The cure rate of Gramnegative aerobic bacillary infections was 87%. No significant influence of initial neutrophil count on response rate was noted, although patients in whom the neutrophil count increased during therapy had a higher response rate (84%) than patients in whom the neutrophil count decreased or remained stable (72%). The combination of ticarcillin and IV sulfamethoxazole-trimethoprim is satisfactory initial empiric antibiotic therapy for febrile episodes in neutropenic patients with cancer.

(Arch Intern Med 1981;141:926-930)


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