We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Platelet Dysfunction in Acute Lymphatic Leukemia

Roy E. Smith, MD; Ghaleb A. Saab, MD
Arch Intern Med. 1981;141(2):269-270. doi:10.1001/archinte.1981.00340020131039.
Text Size: A A A
Published online

To the Editor.  —Qualitative platelet abnormalities predispose to bleeding episodes in patients with acute leukemia.1,2 Although impaired platelet aggregation has been repeatedly observed in acute myelocytic leukemia,3 only three cases of patients with acute lymphoblastic leukemia (ALL) and abnormal platelet function have been previously reported.4 We report here an additional case with a metabolic defect not previously described.

Report of a Case.  —A 13-year-old boy was admitted to the Ohio State University Hospital with a large mediastinal mass and diffuse peripheral lymphadenopathy. The WBC count was 17,200/cu mm, with 12% T-cell lymphoblasts and 35% lymphocytes, and a bone marrow aspirate disclosed diffuse T-cell infiltration. He was treated to complete remission with a combination of cyclophosphamide, vincristine sulfate, doxorubicin, and prednisone. Maintenance treatment consisted of intrathecal prophylaxis followed by mercaptopurine, thioguanine, methotrexate, vincristine sulfate, and cytarabine in various combinations. One year after termination of all therapy, he remains in


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.